This guideline is designed to provide information on organophosphate pesticides, the nature of their toxicity, and biological monitoring of users. It also discusses the various issues to be considered for effective control of health risks from these compounds.

Table of Contents

Introduction
About these Guidelines
Abbreviations
A Summary of the Health and Safety in Employment (HSE) Act 1992
Hazard Management
Information for Employees
Duties of Self-Employed People
What are Organophosphates?
Toxicology of Organophosphates
Symptoms of Organophosphate Poisoning
Other Aspects of Organophosphate Toxicity
Toxicity Differences Between the Organophosphates
Hazards During Use
Requirements for Safe Use
Biological Monitoring for Organophosphates in the Body
Why Monitor?
Who and What to Monitor (Which Users, Which Organophosphates)
How to Monitor (What Tests)
When to Monitor
Interpretation of Results and Management of Users
Criteria for Return to Work
Testing for Diagnostic Purposes
A Word on Prevention

Appendices

Appendix 1: W.H.O. Classification of Organophosphorus Pesticides
Appendix 2: Sources of Variation

Extent and Sources of Variability in pChE and AChE
Physiological Sources of Variation
Pharmacological Sources of Variation
Genetic Sources of Variation
Disease as a Source of Variation

Appendix 3: Explanation of Chosen Criteria for Return to Work

Baseline Test Results Available

Appendix 4: First Aid and Antidotes

Antidotal Treatment
Supportive Treatments

References
OSH Publications
Standards